New anti-tampering technologies and security features along with coding of individual medicine packages can aid in identifying and then reducing harm associated with counterfeiting of medicines. Equally important, however, is effective communication between public sector and private sector actors; this has occurred in the past as evidenced in a joint effort to address a global criminal network. The Pharmaceutical Security Institute is participating in ongoing international efforts to promote the concept of a Single Point of Contact (SPOC) system to further enhance communication amongst the stakeholders. Using this approach, technology and human engagement can promote safety of the global drug supply.