The purpose of this paper is to provide an update and report the current status of the cross-campus University of Colorado Denver program in bioinnovation and entrepreneurship, details of which were first reported in the Journal of Commercial Biotechnology in 20125. The paper outlines the joys and challenges of implementing an inter-campus program that attempts to marry cutting-edge biotechnology innovation with a solid business foundation. The tremendous value offered by such a program, particularly to biotechnology and life-science researchers, is outlined. Operationalization and process issues such as differential tuition rates, distance between campuses, and class timing issues are considered, and solutions are offered. Finally, recommendations are provided for other business schools considering a similar program.